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EGCG has been shown to improve insulin sensitivity through the modulation of insulin signaling pathways

This makes it inevitable to revisit the disorder to identify potential therapeutic targets and explore the potential of purified phytoconstituents to modulate these targets

Interestingly, ectopic expression of CerS1 or treatment with C18-pyridinium-ceramide resulted in LC3-II formation and promoted its direct binding to ceramide on the mitochondrial membranes

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