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Here, after metformin failure, GLP-1 receptor agonists, or SGLT-2 inhibitors are recommended as second line therapy or as third line therapy in combination

doi: 10.1352/0895-8017(2006)111[193:MIPS]2.0.CO;2 6 LiontiTReidSMRowellMM

However, experts have expressed concern that there is little scientific evidence to support the peptides being considered

GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and the GIP/GLP-1 dual agonist tirzepatide influence appetite, satiety, and gastric emptying

BPC-157 exhibits stable protection of gastric mucosa in various injury models, even when administered orally. Drmic, D