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34,75,89 Lastly, non-adherence to antihypertensives remains a major challenge to maintaining adequate BP control and is common in people with T2DM, especially in younger age groups who have the highest lifetime risk of HF
The vascular endothelial dysfunction is a critical step of atherogenesis which is usually characterized by endothelium-dependent vasodilatation and vasoconstriction imbalance and the disturbed balance of antithrombotic and prothrombotic factors 4
preparation of the manuscript
Whether future small-molecule programs can achieve dual or triple receptor agonism in an oral formulation remains one of the most important questions in the field
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