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Fat burners have a meaningful effect at rest through their thermogenic and appetite-suppressing properties, though they work significantly better alongside exercise

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doi: 10.1016/j.addr.2015.07.007 272 Martinez-OutschoornUEBallietRMRivadeneiraDBChiavarinaBPavlidesSWangCet al

Moreover, these analyses have already been done in conventional meta-analyses, showing for SGLT-2 inhibitors the lack of significant difference in the reduced risk of the composite outcome (CV death + HHF) in patients with or without type 2 diabetes or in subjects of 65 years of age or younger vs those older than 65 years of age [13]