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Current evidence supports glutathione's potential as a depigmenting agent but underscores the need for rigorous, large-scale clinical trials to establish long-term safety, optimal dosing, and standardized applications, and until such data are available, clinicians and consumers should exercise caution to ensure safe and effective dermatological practices, particularly with intravenous use

In their paper in Nature Medicine , Bluestone

Vitamin B12 injections can be an effective way to correct deficiency or maintain healthy levels in people who need them

Administration to humans or animals outside of approved research protocols is prohibited

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