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For decades, diet and exercise have been a go-to, but its not uncommon for a person to have tried 20-30 times to lose weight with this approach

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In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12

Finally, expression levels of target genes were determined by the ratio between the levels of target genes and the levels a housekeeping gene ( gapdh )