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Fingolimod protects against ischemic white matter damage by modulating microglia toward M2 polarization via STAT3 pathway

Alanine mutations confirmed that Trp221 and His223 at the surface groove are critical in the formation of the - glucan binding site on Dectin-1, and this site finds to be conserved among Dectin-1 of murine, chimpanzee, rhesus monkey, cow, and humans (168)