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In patients with a history of coronary bypass surgery, 6-month supplementation with L-arginine (6.4 g/d, n = 32, age 65 10) reduces ADMA levels, increases plasma cGMP, and improves reactive hyperemia compared to placebo (n = 32, age 64 11) (Lucotti et al., 2009)

Journal of Molecular Catalysis B: Enzymatic , 125 , 6-15

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COMT (Catechol-O-Methyltransferase) Responsible for breaking down stress hormones like dopamine and adrenaline, a "dirty" COMT gene can make it difficult to manage stress, resulting in anxiety, mood swings, and other emotional challenges

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