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Notably, in vivo reduction of lactate production or inhibition of GPR81-mediated signaling pathways significantly decreases circulating exosomal HMGB1 levels, thereby improving survival outcomes in polymicrobial sepsis [28]

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Given the recent influx of evidence suggesting a connection between the popular diabetes and weight loss drug, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and various ocular adverse events, a new study aimed to investigate this potential association on a global scale

If organ failure persists beyond 48 h, the condition is classified as SAP [1]