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3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)

All statistical analyses were conducted using R statistical software v2.9.2 and the nlme package in Bioconductor v2.4 [17]

Unless otherwise prescribed: At the start of treatment, 1 ml of vitamin B12-Depot-Injektopas 1500 g is administered twice a week in the first few weeks after the diagnosis (corresponding to 3000 g hydroxocobalamin acetate)

Monami M, Bardini G, Lamanna C, et al

This is followed by N-acetylation of the cysteine conjugate, forming a mercapturic acid (Fig