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Major players Novo Nordisk: Semaglutide franchise, advancing into amylin combos (CagriSema) Eli Lilly and Company: Tirzepatide (marketed), Retatrutide (triple agonist), Orforglipron (oral GLP-1) Amgen, Boehringer Ingelheim / Zealand Pharma, Altimmune, Inc., @Roche (via Carmot): all pushing dual and triple incretin strategies with unique angles like NASH benefits or monthly dosing