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Although poor survival may result from large tumor size [13, 30, 31], inadequate margin [13, 15, 30], high-level tumor grade [13,14,15], or presence of distant metastasis [13, 31, 32], prognostic factors have not reached an agreement in literatures

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A systematic review published in eClinicalMedicine analyzed 18 randomized controlled trials involving 3,771 participants and found that discontinuing GLP-1 receptor agonists resulted in an average weight regain of 5.63 kg, along with an HbA1c increase of 0.25%

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