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This is very important because these parameters are used to characterize the development of oxidative or nitrosative stresses under some circumstances, particularly in certain pathologies [9, 10, 27, 146]

Ganz R, Swain M, Traber P, DalCanto M, Butterworth RF, Blei AT (1989) Ammonia-induced swelling of rat cerebral cortical slices: implications for the pathogenesis of brain edema in acute hepatic failure

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The 4.5 mg dose produced 10.8% reduction (11.5 kg average)