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This selective binding initiates both genomic and non-genomic estrogenic responses that disrupt normal hormonal balance ( 3.1.2 Membrane receptor and calcium signaling dysregulation 3.1.2.1 Calcium homeostasis disruption EED exposure significantly disrupts intracellular calcium homeostasis, leading to aberrant Ca 2+ signaling patterns that compromise sperm function
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AOD9604 and Safety Pharmacology Research A conventional Ames test showed no significant mutation rate increase for AOD9604 at up to 2,000 g/plate, with no clastogenic effects observed in CHO-cell chromosome aberration assays
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