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In children that are extremely thin or extremely young that have essentially no fatty tissue on their buttocks, I have found that injections given every day or every-other-day, still just under the skin, seem to overcome the problem and allow the benefits of methyl-B12 to be seen

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Clinical Significance of Low Vitamin B12 Blood Levels When theres not enough B12 in the body, it affects important functions like DNA synthesis, red blood cell (RBC) production, nerve protection, and the breakdown of carbohydrates into energy

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Individual differences in gut microbiota baseline result in heterogeneous therapeutic responses, with some patients possibly showing no improvement or even adverse reactions