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Hereditary cancer syndromes like BRCA1/2 mutations, Lynch syndrome, and Li-Fraumeni syndrome create elevated lifetime cancer risk that persists regardless of current cancer status

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Using the MelaFulKutis 3D pigmented skin model under UV and methylglyoxal exposure, the DEC-containing serum also reduced melanin deposition and downregulated microphthalmia-associated transcription factor (MITF) and TYR expression by 63.37% and 80.39%, respectively