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Foundayo echoes Wegovy - it seems to reduce the risk of heart disease Patients ask me all the time about the safety concerns of these drugs

Gradual dose escalation improves gastrointestinal tolerability.78 Acute pancreatitis is a rare but documented adverse event associated with exenatide use, as reported in the FDA Adverse Event Reporting System and observational studies.79 Current guidelines from the American Association of Clinical Endocrinologists recommend cautious use of GLP-1RAs in T2DM patients with a history of pancreatitis80 (See Figures 2 and 3)

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If symptoms are limiting at a current dose, clinicians will often hold the dose steady or slow the schedule rather than push forward

By selectively augmenting insulin release, modulation of GLP-1R trafficking may be a viable strategy to achieve greater metabolic control in T2D without increasing the rate of unwanted side effects, such as nausea