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Mongioi L, Calogero AE, Vicari E, Condorelli RA, Russo GI, Privitera S, et al

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Whereas, once the tumor turns aggressive, tumor cells express immune checkpoint modulators [such as cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 ligand 1 (PD-L1)] to suppress the immune response

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21 Physical and Mental Exhaustion More women report physical and mental exhaustion during perimenopause than in the premenopausal stage, and the percentage increases after menopause, even when stress levels are low

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