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The number of Th17 cells and the mRNA expression levels of IL-17, IL-17A, IL-21, IL-22, and IL-23 in the inflammatory colonic tissues of active UC were significantly higher than those in inactive UC, healthy controls, and in vitro studies [63,64,65,66]

doi: 10.1038/nchembio.2334 PMID: 28288109 Lazki-Hagenbach P et al (2021): Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells

Meanwhile, the gene level of matrix metallopeptidase nine and tumor necrosis factor related to tumor metastasis exhibits a downward trend in SLC25A22-silenced cancer cells, indicating inhibition of GSH synthesis may play a critical role in the treatment of cancer metastasis (Wong et al., 2016)

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