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doi: 10.1177/0115426592007004175 379

Careful monitoring of blood pressure is recommended when initiating therapy in hypertensive patients, and those with baseline low blood pressure should use B-containing injections cautiously

In neurons, excess intracellular zinc impairs mitochondrial function by dissipating the membrane potential, inhibiting ATP production, increasing ROS generation and permeability transition, disrupting calcium homeostasis and altering mitochondrial dynamics, contributing to neurodegenerative processes 153,154

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It also notes GHK-Cus ability to influence gene expression and promote cellular repair processes that decline with age