The PAB model was surgically created by placing a constrictive band around the pulmonary artery (PA) to induce pressure overload
The medication is started at a low dose to help the body adapt and reduce the risk of side effects
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Self-monitoring at home should include: Weight tracking : Weekly weigh-ins at the same time of day, recorded in a diary or app, help identify trends whilst avoiding obsessive daily fluctuations Blood glucose monitoring : Patients with diabetes should test as advised by their healthcare team, typically including fasting and pre-meal readings, with increased frequency during dose adjustments Symptom diary : Recording side effects, appetite changes, and general wellbeing helps identify patterns and informs clinical discussions Dietary and activity logs : Tracking food intake and physical activity provides context for weight and glucose changes Clinical monitoring typically follows this schedule: 46 weeks : Initial review to assess tolerability, side effects, and early response
Supplementary Information Acknowledgements We thank all who actively participated in and provided statistical support for the study
