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Men with higher baseline lean mass may tolerate 2ml weekly protocols more readily, but efficacy doesnt scale linearly with dose response depends more on hepatic lipid burden and dietary structure than sex or body size

or synthesis of the peptide fragment II: synthesis of the peptide fragment IV: Cys19-Gly31

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Thus, as predicted by RNA-Seq, leptin and CCK signaling was compromised in Bbs5 / mice, which may explain at least in part the hyperphagic phenotype in BBS