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Research published in Biochemical Pharmacology demonstrated that treating cells with 5-Amino-1MQ effectively blocks this leak. It inhibits NNMT, forcing Nicotinamide back into the salvage pathway

936 Boudehen et al

Phentermine has no direct effect on blood sugar beyond what weight loss itself provides

Last reviewed: May 31, 2026 Last updated: May 31, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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